A parasite protein has been found to be a promising new treatment for wound healing

In a new study published in the journal Life Science Alliance, a research team led by Professor William C. Gause, director of the Rutgers University Center for Immunity and Inflammation, revealed that a protein produced by intestinal parasites, TGM, can significantly accelerate the healing of skin wounds in mice and reduce the formation of scar tissue.

The study, published on August 23 and given a 100/100 rating by NewsGuard, indicates the quality and reliability of the research. The study found that applying TGM protein directly to skin wounds in mice not only accelerated the wound-healing process but also promoted normal skin regeneration and effectively inhibited scar formation.

Rapid closure of skin wounds is essential to prevent infection, but this process is often accompanied by the formation of scar tissue. The balance between scar tissue formation and successful tissue regeneration is strongly influenced by immune cells recruited to the wound site. Professor Gause's team focused on finding ways to enhance the activity of immune cells that promote regeneration while suppressing the activity of immune cells that promote scarring.

The research team found that TGM protein stimulates immune cells such as macrophages to enter the wound by binding to TGF-b receptors and reprogramming them to promote tissue regeneration. This discovery provides an important framework for the development of new treatments for skin wounds, which is expected to promote wound healing in human patients.

"We have developed a new therapeutic approach for the treatment of skin wounds that favors regenerative wound healing rather than tissue fibrosis and scar formation," said Professor Gause. "This study provides important scientific foundation for the use of easily produced parasite proteins as therapeutics to promote skin wound healing."

This study not only provides new treatment ideas for the medical community but also lays the foundation for possible clinical applications in the future. With further research, TGM protein is expected to become an important tool to promote human wound healing and reduce scar formation.

The Rutgers Center for Immunity and Inflammation is a multidisciplinary research and education center dedicated to studying the role of the immune system in health and disease and how this knowledge can be used to develop new therapeutic strategies.

source:

Rockefeller University Press