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Silver is a natural antibacterial material that has been used by humans for thousands of years. Silver has a broad antibacterial spectrum and is not easy to develop drug resistance. Silver can reduce the bacterial load on wounds, accelerate wound healing, and treat infections. It can also be used in wound dressings, infusion tubes, etc. It is mainly used for the treatment of chronic wounds, and is commonly used in post-operative injury and repair.
Silver-containing dressings refer to a class of dressings that contain silver compounds or nano-silver to obtain antibacterial properties by releasing silver ions or nano-silver particles. The main dressing substrates loaded with silver compounds or nano-silver include: medical absorbent cloth, non-woven cloth, polymer materials, carbon fiber, hydrogel, alginate, etc. Different substrates have differences in physical properties such as water absorption, moisture retention, and breathability. Select suitable silver-containing dressings for different clinical wound applications.
For silver to exert antibacterial activity, it must be present in solution, such as silver ions or nanosilver.
Different antibacterial mechanisms of silver ions and compounds VS nano-silver
Silver ions and compounds:
Silver ions combine with negatively charged bacteria to enhance the permeability of bacterial outer membrane and induce bacterial apoptosis;
Silver ions enter bacteria and combine with active sulfhydryl and amino groups on various metabolic enzyme proteins of bacteria to inactivate the enzyme proteins, thereby interfering with bacterial energy metabolism and inhibiting bacterial growth and reproduction;
Silver ions combine with bacterial DNA or RNA to prevent their replication and destroy bacterial reproduction, thereby inhibiting or killing bacteria;
Inhibit the formation of bacterial biofilm.
Nano silver(ag+):
Nanoparticles refer to particles between 1-100 nm in diameter. Due to quantum effect, small size effect and large specific surface area, nano-silver can easily enter pathogens and play an antibacterial effect. In terms of effective concentration, nano-silver is at the nanomolar level, while silver ions are at the micromolar level. Nano-silver provides silver in 0-valent form, which is usually not combined with halides, has stronger and longer-lasting antibacterial effects than silver ions, and easily induces the generation of reactive oxygen species to exert antibacterial effects.
